CIMIT Forum: SCI-Induced Osteoporosis: Impact of Spinal Cord Injury on the Bone Microenvironment

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SCI-Induced Osteoporosis:
Impact of Spinal Cord Injury on the Bone Microenvironment

1.26.2010

SPEAKER:
Leslie Morse, DO, Clinical Associate, MGH; Staff Physician, Spaulding Rehabilitation Hospital and Spinal Cord Injury Service, VA Boston Healthcare System; Instructor, Harvard Medical School

MODERATOR:
Thomas Brady, MD, CIMIT Co-Program Leader, Cardiovascular Disease; Director of Cardiovascular Imaging and Intervention and Director of Radiology Research, Massachusetts General Hospital; LL Robbins Professor of Radiology, Harvard Medical School; visiting professor, MIT Sloan School

Forum Abstract

SCI results in rapid and severe osteoporosis leading to increased risk of lower extremity fracture. Although the mechanism(s) of SCI-induced osteoporosis are unclear, it is thought to alter cellular activity within the bone microenvironment. Leslie Morse will review the cellular changes that occur immediately following SCI in rodents and identify potential cellular targets involved in bone regeneration due to FES-rowing.