Forum Summary

Critical care involves aspects of a variety of medical fields, and research conducted in the laboratory of Daniel Kohane, MD, PhD, has dealt with a variety of clinical challenges.  He and collaborators have worked to design prolonged duration localized anesthetics to manage pain, and they have created a number of formulations, including a sensory selective nerve block using a lidocaine derivative and a chemical permeation enhancer.  They have also worked to design drug-eluting contact lenses and endotracheal tubes in the hopes of preventing infections.  Fungal infections are a major problem in immunocompromised patients and in patients with implanted devices, so Dr. Kohane and collaborators have also created antifungal hydrogels.   Other projects include efforts to create biocompatible films capable of preventing peritoneal adhesions after surgery and nanoparticles capable of being targeted to a specific site using light.  Taken together, these projects demonstrate how materials science can be used to improve patient outcomes.      

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