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CIMIT Announces $3 Million in Medical Research Grants

Awards will support projects targeting brain injuries, pain management, and innovations in healthcare delivery systems.

A wide variety of early-stage, healthcare technology innovation projects in NeuroHealth, Traumatic Stress Disorders, and integrated clinical environments were among those chosen to receive more than $3 million in CIMIT seed grants for FY11.

From seeking novel approaches in the Interoperability of portable X-Ray machines with ventilators in monitored settings to a pilot telehospice project that connects patients at end of life to providers in an effort to reduce rehospitalization, these innovative approaches seek to improve patient care and control healthcare costs. 

Also selected for award are projects to benefit America’s wounded warriors through a novel application of intranasal Huperzine A in treatment of traumatic brain injury and a low-cost, low maintenance mechanical ventilator for use on the battlefield, in the developing world or in the event of mass casualty.

And among the seven projects selected to launch the CIMIT consortium-wide strategic initiative on Integrated Clinical Environments is an inter-institutional collaboration focused on using network analysis to improve the qualities of neonatal intensive care teams and their work flow functions.

Each of the thirty, $100,000 grants will support a multidisciplinary research team that is developing an innovative medical device or clinical system. A key goal of the CIMIT grant program is to bring together entrepreneurial scientists, often from different institutions, to accelerate medical innovation so that better care can be delivered to patients more quickly.

Through the award of seed grants and facilitation, CIMIT helps to launch new or translational research projects that will then produce enough results to be able to secure outside funding for further development.

CIMIT CEO John A. Parrish, MD remarked, “We are determined to help improve healthcare.”  He went on to explain, “By supporting promising innovation, we are enabling clinicians and engineers to work together and ultimately to discover novel methods that provide better treatment more quickly.”

The thirty successful proposals were selected from 195 applications submitted by inter-institutional research teams from across the CIMIT consortium of twelve institutions.  Of the 30 projects selected for support:

  • over one-third of these awards are in the CIMIT NeuroHealth initiative — projects in the areas of neurotechnologies, traumatic brain injury (TBI), neurotrauma, traumatic stress disorders (PTSD), and pain management; 
  • seven projects will help advance the Integrated Clinical Environments initiative — a consortium-wide effort to help transform healthcare delivery systems and advance the integration of clinical care within all care environments; and
  • nearly two-thirds of these projects have direct relevance to improving care for wounded warriors. These novel innovations will improve care of the injured soldier on the battlefield, during evacuation and in other trauma care settings. Other projects are focused on the needs of veterans during rehabilitation and in managing chronic conditions.

“We were very impressed by the quality of proposals and the new opportunities to truly impact how care is delivered,” said Steven Schachter, MD, Chief Academic Officer. “Teams brought together by these grants have the chance to make a major difference in innovative medicine.”

Recipients of FY11 CIMIT Innovation Grants are:

Principal Investigator Project Title Institution Program Area
Nathalie Agar
Intraoperative Stereotactic Molecular Imaging of Tumor Boundaries by Mass Spectrometry
BWH
Image Guided Therapy
William Anderson
Memory Alteration through Theta Phase-Locked Electrical Stimulation
BWH
NeuroHealth
Emilio Bizzi
A Fully Autonomous Brain-Body Interface for Patients with Neuromuscular Injury or Disease
MIT
NeuroHealth
Colleen Channick
Creation of Amino Alcohol-Based Poly(ester amide) Elastomer Bioabsorbable Airway Stent
MGH
Biomaterials & Tissue Engineering
Pedro del Nido
Catheter-based adaptable device for closure of intracardiac defects in children
CHB
Cardiovascular Disease
Elazer R. Edelman
Multi-Parameter Assay For Modulating Thrombotic Therapy
MIT
New Initiatives
Julian Goldman
PCA Monitoring Safety Interlock to Decrease Adverse Clinical Events
MGH
Clinical Systems Innovation / Integrated Clinical Environment
James Gray
Using network analysis to improve the qualities of NICU care teams and their function
BIDMC
Clinical Systems Innovation / Integrated Clinical Environment
R. Scott Harris
Enhanced inhalation therapy for emphysema
MGH
Inhalation Technology
Carl Hauser
A Rapid PCR-Based, Point of Care Test To Discriminate Between Sterile and Infective SIRS
BIDMC
Biodetection & Sepsis Control
Joel Karlinsky
Interoperability of Portable X Ray Machines with Ventilators in Monitored Settings
VA BHS
Clinical Systems Innovation / Integrated Clinical Environment
Shalesh Kaushal
Low Energy Laser as a Therapeutic for Dry Age-related Macular Degeneration
U Mass Med School
NeuroHealth
Yong-Tae Lee
Improving Recovery after Stroke via Electrical Stimulation of Proprioceptors
Harvard
NeuroHealth
Alexander Lin
Neurochemical and Multimodal Biomarkers for Chronic Traumatic Encephalopathy
BWH
Traumatic Brain Injury / NeuroHealth
Frank Moss
Collaborative Virtual Rehabilitation Interface with Home Treatment Integration
MIT
Clinical Systems Innovation / Integrated Clinical Environment
Joanne Nowak
Telehospice Pilot to Connect Patients at End of Life and their Families to Providers to Reduce Rehospitalization and Control Healthcare Costs
Partners Hospice
Clinical Systems Innovation / Integrated Clinical Environment
Lauren O'Donnell
Diagnosis of diffuse axonal injury using robust tract-based quantification of diffusion tensor imaging
BWH
Traumatic Brain Injury / NeuroHealth
Scott Orr
Event-related P2 slope as a predictor of response to SSRIs in a veteran population
VA BHS
Traumatic Stress Disorders
Alvaro Pascual-Leone
Noninvasive, Physiologic Characterization of Cortical Plasticity After Mild Traumatic Brain Injury in Humans-392
BIDMC
Traumatic Brain Injury / NeuroHealth
Nira Pollock
Development of a Novel Paper-based Point-of-care Test for Liver Function
BIDMC
Global Health Initiative
Robert Redmond
Preventing Leakage from Colon Anastomosis Sites
MGH
Trauma & Casualty Care
Alexander Rotenberg
A novel application of intranasal Huperzine A in treatment of traumatic brain injury
CHB
Traumatic Brain Injury / NeuroHealth
Dianne Sacco
Advanced Ureteroscope Navigation System for Calculi Removal
MGH
Image Guided Therapy
Jussi Saukkonen
Low-Cost, Low Maintenance Mechanical Ventilator for Developing World or Mass Casualty
BU
Inhalation Technology
Jussi Saukkonen
Development of an interactive, clinical algorithm-driven interoperable smart ventilator.
BU
Inhalation Technology / Integrated Clinical Environment
Balachundhar Subramaniam
Echocardiography guided central oximetry-198
BIDMC
Optical Diagnostics
Christopher Thompson
Utilization of a Novel Kinematics System to Improve Quality in Colonoscopy
BWH
Simulation
Junichi Tokuda
Robot-assisted laparoscopic prostatectomy guided by patient-specific models
BWH
Image Guided Therapy
Peter Warnke
Physiologically-guided stereotactic radiosurgery in MTLE
BWH
NeuroHealth
Kim Wilson
Using Mobile Electronic Protocols to Improve Newborn Survival in Developing Country Settings
CHB
Global Health Initiative / Integrated Clinical Environment

CIMIT
A clinically-based consortium of Boston-area hospitals and engineering schools, CIMIT supports translational research by multidisciplinary teams for medical device and clinical technology system applications.  CIMIT attracts world-class clinicians, scientists and engineers working together with industry and government to accelerate the clinical impact of innovative technologies.


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