High-Risk Plaques: Detection and Management

May 3-4, 2008

The Colonnade Hotel

Boston, MA

Course Directors:

Thomas J. Brady, MD, Massachusetts General Hospital and CIMIT
Ahmed A. Tawakol, MD, Massachusetts General Hospital and CIMIT

Offered by:

Center for Integration of Medicine and Innovative Technology (CIMIT)
Harvard Medical School
Massachusetts General Hospital

Saturday, May 3
7:00 - 8:00 AM	Registration
8:00	Welcome	Ahmed Tawakol, MD
8:15-11:30	Session 1: Pathophysiology of Atherosclerosis
8:15 – 8:45	Defining the Vulnerable Plaque: New Pathologic Insights	Renu Virmani, MD, FACC
8:45 – 9:30	Inflammation and the Pathogenesis of Atherosclerosis	Peter Libby, MD
9:30-10:00	Break
10:00 – 10:30	Inflammatory Triggers of Plaque Rupture	Mohammad Madjid, MD
10:30 – 11:00	Mechanisms of the Acute Coronary Syndromes	Peter Libby, MD
11:00 – 11:30	Discussion
11:30 AM to 12:30PM	Lunch
12:30 to 5:20 PM	Session 2: Non-Invasive Detection Modalities
12:30 – 1:00	Biomarkers Overview	Paul Ridker, MD
1:00 – 1:30	What has Framingham Taught Us?	Christopher O’Donnell, MD, MPh
1:30 – 2:00	Lipids	Ernst Schaefer, MD
2:00 – 2:30	Discussion
2:30-2:45	Break
2:45 – 3:10	Imaging Biomarker Overview	Udo Hoffmann, MD
3:10 – 3:35	Carotid Ultrasonography	Marie Denise Gerhard-Herman, MD
3:35 – 4:00	CT	Thomas Brady, MD
4:00 – 4:25	Positron Emission Tomography	Ahmed Tawakol, MD
4:25 – 5:00	MRI	Thomas Brady, MD
5:00-5:20	Discussion
5:20	Adjourn
5:20 – 6:00	Reception

Sunday, May 4
8:00 AM -12:15 PM	Session 3: Invasive Detection Modalities
8:00 – 8:30	Coronary Arteriography	Pallav Garg, MBBS, FRACP, MSc
8:30 – 9:00	IVUS and Virtual Histology	Geoff Vince, PhD
9:30 – 9:30	Endothelial Shear Stress	Peter Stone, MD
9:30 –10:00	Discussion
10:00 –10:15	Break
10:15 – 10:45	Intravascular MRI and NIRF	Farouc Jaffer, MD, PhD
10:45 – 11:15	Near-Infrared Spectroscopy	James Muller, MD
11:15 – 11:45	OCT	Guillermo Tearney, MD, PhD
11:45 –12:15	Discussion
12:15 –1:30	Lunch
1:30 – 4:00	Session 4: Management of High-Risk Plaques
1:30 – 2:00	Optimal Lipid Management	Jorge Plutzky, MD
2:00 – 2:30	Non-Lipid Pharmacotherapy	Ahmed Tawakol, MD
2:30 – 3:30	Should Drug-Eluting Stents Be Used to Treat VP?
	Yes	Pallav Garg, MBBS, FRACP, MSc
	No	Aloke Finn, MD
3:30-4:00	Discussion
4:00	Adjourn

2008 Faculty

Thomas J. Brady, MD

Co-Program Leader, CIMIT Cardiovascular Disease Program; Director, Cardiovascular Imaging and Intervention; Director, Nuclear Medicine and Molecular Imaging and Vice Chairman, Director of Radiology Research, Massachusetts General Hospital; L.L Robbins Professor of Radiology, Harvard Medical School

Aloke Finn, MD
Assistant Professor of Medicine, Emory University School of Medicine

Pallav Garg MBBS, FRACP, MSc
Division of Clinical Biometrics, Department of Cardiology, Brigham and Women's Hospital

Marie Denise Gerhard-Herman, MD
Medical Director, Vascular Diagnostic Laboratory, Brigham and Women’s Hospital

Udo Hoffmann, MD

Associate Professor of Radiology, Harvard Medical School; Director, Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital

Farouc Jaffer, MD, PhD

Assistant Professor of Medicine, Harvard Medical School; Director, Vascular Imaging, Cardiovascular Molecular Imaging Program; Attending Interventional Cardiologist, Cardiac Catheterization Laboratory, Massachusetts General Hospital

Peter Libby, MD

Mallinckrodt Professor of Medicine, Harvard Medical School, Chief of Cardiovascular Medicine, Brigham and Women’s Hospital

Mohammad Madjid, MD

Senior Research Scientist, Texas Heart Institute

James Muller, MD

Founder, CEO, President and Chief Medical Officer, InfraRedx

Christopher O’Donnell, MD, MPh
Assistant Professor of Medicine, Harvard Medical School; Cardiology, Department of Medicine,

Massachusetts General Hospital

Jorge Plutzky, MD

Associate Professor of Medicine, Harvard Medical School; Director, The Vascular Disease Prevention Program, Brigham and Women’s Hospital

Paul Ridker, MD

Eugene Braunwald Professor of Medicine, Harvard Medical School; Director of the Center for Cardiovascular Disease Prevention, Brigham and Women’s Hospital

Ernst J. Schaefer, MD
Senior Scientist and Director, Lipid Metabolism Laboratory; Jean Mayer USDA HNRCA at Tufts University

Peter H. Stone, MD

Associate Professor of Medicine, Harvard Medical School; Co-Director, Cardiac Care Unit and Director, Clinical Trials Center, Brigham and Women’s Hospital

Ahmed A. Tawakol, MD
Co-Program Leader, CIMIT Cardiovascular Disease Program; Co-Director, Cardiac MR-PET-CT Program and Associate Director, Nuclear Cardiology, Massachusetts General Hospital

Guillermo Tearney, MD, PhD

Associate Professor of Pathology, Harvard Medical School; Wellman Center for Photomedicine, Massachusetts General Hospital; Program Leader, Optical Diagnostics, CIMIT

Geoff Vince, PhD

Vice President of Clinical and Scientific Affairs, Volcano Corporation

Renu Virmani, MD

President and Medical Director, CVPath, Institute, Inc.