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CIMIT Summer Education Series 2010:
Emerging Technologies and Applications for Therapeutic Delivery of Drugs and Molecules

For four weeks in July 2010, the CIMIT Forum Summer Education Series offered attendees the opportunity to build an understanding of novel methods of drug delivery and drug/device combination therapy. Expert scientists, engineers, and clinical leaders who are developing new technologies and translating them into clinical solutions lectured weekly at the Boston University Photonics Center.  The goal was to link current and evolving technologies with unmet clinical needs.

On July 6th, Jeffrey Karp, PHD, spoke about the next generation of biomaterials and chemical approaches to control cellular response. Ying Mei, PHD discussed high throughput development of biomaterials for stem cell engineering. On July 13th, Omid Farokhzad, MA, MD spoke about multifunctional polymeric nanoparticles for medical applications, and Michael Cima, PHD discussed convergence products including drug delivery devices and devices for diagnostics. On July 20th, David Nathan, MD, PHD, spoke about the clinical importance of new methods of drug delivery focusing on the case for diabetes. Robert Langer, SCD, discussed the past, present, and future of drug delivery technology. On July 27th, Yolanda Colson, MD, PHD, spoke about novel drug delivery platforms for cancer, and Daniel Kohane, MD, PHD, discussed the applications of novel biomaterials and drug delivery technologies for anesthesia and critical care therapies.

Through the series, the speakers demonstrated the immense potential for impact on human health. Future applications could include molecules that silence genes, nanotechnology based systems that could target drugs to specific sites in the body, and new systems where the medicine is administered continuously based on the patients’ needs.  Novel drug delivery technology will optimize safety and effectiveness while reducing side effects.

DATE / LOCATION TITLE SPEAKERS
July 6, 2010

4:00 to 6:00 PM

Boston University Photonics Center


High Throughput Development of Biomaterials for Stem Cell Engineering

Jeffrey Karp, PhD
Harvard-MIT Division of Health Sciences and Technology/MIT

Ying Mei, PhD
MIT

Moderator: Frederick Schoen, MD, PhD
BWH


RELEVANT ARTICLES:

Nature Nanotechnology: Nanocarriers as an emerging platform for cancer therapy

PubMed: Interplay of biomaterials and micro-scale technologies for advancing biomedical applications

Technology Review: Nano RNA Delivery

BioMedExperts: Lipid-like materials for low-dose, in vivo gene silencing - Proceedings of the National Academy of Sciences of the United States of America 

 

DATE / LOCATION TITLE SPEAKERS
July 13, 2010

4:00 to 6:00 PM

Boston University Photonics Center

NOVEL DELIVERY METHODS

Medicinal Nanoengineering: Multifunctional Polymeric Nanoparticles for Medical Applications

Drug, Diagnostic, Device, or Procedure?

 

Omid Farokhzad, MD
BWH


Michael Cima, PhD
MIT

Moderator: Mark Grinstaff, PhD
Boston University


RELEVANT ARTICLES:

ACS Nano: Impact of Nanotechnology on Drug Delivery

PubMed: Nanotechnology for drug delivery: the perfect partnership

PubMed: HER-2-targeted nanoparticle-affibody bioconjugates for cancer therapy

SpringerLink: Application of Micro- and Nano-Electromechanical Devices to Drug Delivery

PubMed: Resorbable polymer microchips releasing BCNU inhibit tumor growth in the rat 9L flank model

 

DATE / LOCATION TITLE SPEAKERS
July 20, 2010

4:00 to 6:00 PM

Boston University Photonics Center

INTRODUCTION TO DRUG DELIVERY: CLINICAL NEED AND TECHNOLOGICAL SPECTRUM

Clinical Importance of New Methods of Drug Delivery: The Case for Diabetes

Drug Delivery Technology: Past, Present and Future

David Nathan, MD
MGH

Robert Langer, ScD
MIT

Moderator: Elazer Edelman, MD, PhD
MIT


RELEVANT ARTICLES:

JAMA: Careers in Translational Clinical Research—Historical Perspectives, Future Challenges

DATE / LOCATION TITLE SPEAKERS
July 27, 2010

4:00 to 6:00 PM

Boston University Photonics Center

CLINICAL APPLICATIONS

Novel Therapies for Cancer



Anesthesia and Critical Care Therapies

Yolonda Colson, MD, PHD
BWH

Daniel Kohane, MD, PhD
Children's Hospital

Moderator: Jeffrey Borenstein, PhD
Charles Stark Draper Laboratory


RELEVANT ARTICLES:

PubMed: Prevention of local tumor recurrence following surgery using low-dose chemotherapeutic polymer films

PubMed: Expansile nanoparticles: synthesis, characterization, and in vivo efficacy of an acid-responsive polymeric drug delivery system

PubMed: pH-triggered microparticles for peptide vaccination

PubMed: In situ cross-linkable hyaluronan hydrogels containing polymeric nanoparticles for preventing postsurgical adhesions

 

 



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