4:00PM Integrated Sleep Stability: Dynamic Mapping
of Sleep Oscillations in Health and Disease
Robert Thomas, MD, Assistant Professor of
Medicine at Harvard Medical School and Beth Israel Deaconess Medical Center,
rthomas1@bidmc.harvard.edu
Moderator: Ary L. Goldberger, MD, Director, The Margret & H. A. Rey
Institute for Nonlinear Dynamics in Medicine (ReyLab), BIDMC; Program Director,
Research Resource for Complex Physiologic Signals,
agoldber@caregroup.harvard.edu
Traditional approaches to sleep physiology utilize a graded methodology:
characterizing increasing depths of non-REM or type (REM vs. non-REM). Dr.
Thomas will present a new method: mapping integrated / coupled sleep
oscillations, using a single channel of ECG. The resultant "sleep
spectrogram" is rich in "hidden" biological information. He
will present and discuss several examples, including tracking interactions of
chemoreflex control with upper airway mechanics in sleep apnea. The ease of
recording ambulatory ECG allows for repeat testing and dynamic tracking of
physiology in health and disease.
5:00PM Modeling the Dynamics of Sleep Using State
Space Analysis
Tom Scammell, MD, Associate Professor of
Neurology at Harvard Medical School and Beth Israel Deaconess Medical Center,
tscammel@bidmc.harvard.edu
Moderator: Clifford B. Saper, MD, PhD, James Jackson Putnam Professor of
Neurology, HMS; Chairman, Department of Neurology, BIDMC,
csaper@bidmc.harvard.edu
Sleep disorders such as insomnia, sleep apnea, and narcolepsy affect about 30%
of the population and substantially impair driving, school and work
performance, and many other facets of life. Sleep and wake states are complex,
and our understanding of sleep and sleep disorders is limited by current sleep
research techniques. Dr. Scammell will describe a new state / space analysis
technique based upon spectral characteristics of the electroencephalogram that
provides useful perspectives on the causes of sleepiness in narcolepsy and
other sleep disorders.