CIMIT ModelClinical ImpactCommunity: CoLabContact Us
Minimally Invasive Surgery (MIS)


Minimally Invasive Surgery (MIS) decreases risk and shortens post-surgical recovery time. Improved minimally invasive techniques, like laparoscopic surgery, are most effective when the tools are flexible, sophisticated, and incorporate advanced imaging techniques.

New devices, better optics and creative multimodal approaches to disease management have set the stage for the next phase of less invasive surgical therapy.

CIMIT’s Minimally Invasive Surgery progam is focused on making surgery safer and more precise, exploring the next generation of less invasive surgical therapy. Recent projects involve developing tools and procedures for Natural Orifice Translumenal Endoscopic Surgery (NOTES), which could make surgery completely free of incisions, while reducing pain and disability.  Through the NOTES initiative, complex surgeries could eventually become outpatient procedures. 


Medical News Today: World First: Rectal Tumor Removed Through Anus, Avoiding Painful Abdominal Incisions

VIDEO: Transanal Endoscopic Microsurgery (TEM)

Additional Coverage on TEM Surgery: EndoNurse, EurekAlert!, LittleAbout,,,

: You Want To Take My What Out Of My Where? Hospitals Experiment With Orifice Surgery

  • Projects
  • Publications
  • Forum/Events
  • In The News
FY 2010 - 2008
Minimally Invasive Surgery Projects
2010 - 2008 David Rattner, MD, and Chris Thompson, MD, MSc Massachusetts General Hospital & Brigham and Women’s Hospital Strategic Project on Natural Orifice Translumenal Endoscopic Surgery
2008 Peter Masiakos, MD Massachusetts General Hospital Development of an Endoscopic Fiberoptic Device and Biodegradable Scaffolds for Minimally Invasive Closure of Tracheosophageal Fistulas and Patent Foramina
2008 Nathan McDannold, PhD Brigham and Women’s Hospital Herceptin delivery to breast cancer metastases in the central nervous system via focused ultrasound-induced blood-brain barrier disruption
2008 Marvin Ryou Brigham and Women’s Hospital Systematic Mapping of NOTES Access Sites in Human Cadavers
2008 Marvin Ryou Brigham and Women’s Hospital Magnetic Retraction for Advanced NOTES Procedures
Recent Publications by CIMIT Investigators
Willingham, F. F., Gee, D.W., Lauwers, G., Brugge, W. R., Rattner, D. W. Surg Endosc.
Natural Orifice Transesophageal Mediastinoscopy and Thoracoscopy 2008
Alam, H. B., Shults, C., Ahuja, N., Ayuste, E. C., Chen, H., Koustova, E., Sailhamer, E. A., Li, Y., Liu, B., de Moya, M., Velmahos, G. C. Resuscitation
Sep 4, 2007
Impact of Resuscitation Strategies on the Acetylation Status of Cardiac Histones in a Swine Model of Hemorrhage 2007
Sailhamer, E. A., Chen, Z., Ahuja, N., Velmahos, G. C., de Moya, M., Rhee, P., Shults, C., Alam, H. B. J Am Coll Surg 204(4):642-53 Profound Hypothermic Cardiopulmonary Bypass Facilitates Survival without a High Complication Rate in a Swine Model of Complex Vascular, Splenic, and Colon Injuries 2007
Velmahos, G. C., Spaniolas, K., Duggan, M., Alam, H. B., Tabbara, M., de Moya, M., Vosburgh, K. J Trauma 63(2):285-8, discussion 288-90 Abdomainal Insufflation for Control of Bleeding After Severe Splenic Injury 2007
Stahl, J.E., Goldman, J.M., Rattner, D.W., Gazelle, G.S. J. Surg Res. Related Articles, Links Adapting to a New System of Surgical Technologies and Perioperative Processes Among Clinicians 2007 Jan. 31 (Epub ahead of print)
Ryou, M., Rattner, D., Pai, R., Thompson, C. Surg Endosc. 12:677-80 Evaluating an Optimal Gastric Closure Method for Trans-Gastric Surgery 2007
Pai, R., Fong, D.G., Bundga, M.E., Odze, R.D., Rattner, D.W., Thompson, C.C. Gastrointestinal Endoscopy 64:428-34 Transcolonic endoscopic cholesystectomy: a NOTES survival study in a porcine model. 2006
Rattner, D.W. Surg Endosc 20:1802-8 Innovation, Disruption and the perils of success. 2006
Rattner, D.W., Kalloo, A. Surg Endosc. 20:329-33 The ASGE/SAGES Working group on Natural Orifice Transluminal Endoscopic Surgery WHITE PAPER 2006
Minimally Invasive Surgery at the
CIMIT Forum and Past Events
Forum: Minimally Invasive Surgery May 27, 2008

Ali Tavakkolizadeh, MB, BS: Harvard Medical School

Dennis Fowler, MD:
NewYork-Presbyterian Hospital

• Minimally Invasive Surgery
for GI Cancer

• Single Port Laparoscopy or NOTES: A Form of Image Guided Therapy?

Forum: Current Therapies for BPH and the Search for Smart Engineering Solutions Feb. 12, 2008

Shahin Tabatabaei, MD: MGH

Kevin Loughlin , MD: BWH

Michael Callum, MD:
North Shore Medical Center

• Laser BPH Therapy

• BPH Medical Therapy

Forum: Challenges and Opportunities in Office-Based Medicine Oct. 9, 2007 Keith Isaacson, MD; HMS, BWH, BWH

Fred Shapiro, DO; HMS, BIDMC

Beverly Philip, MD; HMS, BWH

Lisa Warren, MD; MGH

• Office-based Gynecologic Procedures

• Office-based Anesthesia 

• Technology Implications of Office-based Anesthesia Safety

• Regional Anesthesia in the Office Based Setting

Minimally Invasive Surgery News
World First: Rectal Tumor Removed Through Anus, Avoiding Painful Abdominal Incisions Medical News Today Dec. 3, 2009
You Want To Take My What Out Of My Where? Hospitals Experiment With Orifice Surgery June. 22, 2009
A New Way to Perform Surgery KTVU Channel 2 Jul. 15, 2008
Surgery Revolution Philadelphia Bulletin May 15, 2008
Open Wide. No, Wider. Are we ready for an era of 'natural-orifice surgery'? Newsweek Apr. 14, 2008
Scar-Free Surgery: In New Operation, Doctors Insert Tools Through Natural Orifices, Keeping Skin Intact Boston Globe Jan. 7, 2008
Novel NOTES Causes Docs to Rethink Incision Decision Boston Business Journal Jul. 13, 2007
Hype, Theories on NOTES Abound, But Where It Is All Headed Is Anyone’s Bet (PDF)             Gastroenterology & Endoscopy News Jul. 2007
A New Step in Scarless Surgery Proto Summer 2007
Video: CIMIT Life-Saving Innovation in Early Stage of Trauma.

David Rattner, MDProgram Leader
David Rattner, MD

Program Leader,
Minimally Invasive Surgery


CIMIT Community

Sign up to keep informed about the CIMIT Minimally Invasive Surgery Program and Community.

Enter your email in form below:

Related Links

VIDEO: David Rattner at Ideas Boston

VIDEO Q&A with David Rattner, MD:
» What is NOTES?
» NOTES vs. Endoscopy
» What is TEM?
» TEM Procedure and Collaboration
» What is the Boston-based NOTES Initiative?
» Is NOTES an Improvement over Traditional Laparoscopic Procedures
» What Procedures Might Benefit from the NOTES Approach?
» What is a Typical Minimally Invasive Thoracic Procedure?
» What is the Potential for NOTES?
» NOTES vs. Single-Port Surgery
» The Evolution of NOTES
» The Role of CIMIT
» When might Patients Benefit from NOTES?

NOSCAR: Natural Orifice Surgery Consortium for Assessment and Research

ASGE: American Society for Gastrointestinal Endoscopy

SAGES: Society of American Gastrointestinal and Endoscopic Surgeons

Operating Room of the Future

MD Plug-and-Play


Press Releases &
Fact Sheets

» July 2010: NOTES Progress Report

Strategic Project Award: CIMIT supports NOTES initiative with $2.1M grant

CIMIT Strategic Project Fact Sheet

NOTES Facts Sheet

NOTES: A Clinical Review


Integrated Clinical EnvironmentsNeuroHealth, PTSD & TBI Industry I Foundation Engagement Homebase & Warfighter CareAccelerator

CIMIT does not rate, endorse, recommend or prescribe any products, procedures or services. Subscribe to CIMIT News in RSS

Contact the Webmaster Site Acknowledgements Copyright © 2011 CIMIT. All rights reserved. site map linking policy privacy